Job Information

  • Description:
    Your mission :
    The EPFL Blue Brain Project (BBP), situated on the Campus Biotech in Geneva, Switzerland, applies advanced neuroinformatics, data analytics, high-performance computing and simulation-based approaches to the challenge of understanding the structure and function of the mammalian brain in health and disease. The BBP provides the community with regular releases of data, models and tools to accelerate neuroscience discovery and clinical translation through open science and global collaboration.

    Within the Laboratory for Neural Basis of Brain States we are looking for a Post-doctoral Researcher in Thalamo-cortical Circuitry
     
    Main duties and responsibilities include :
    The goal of this project is to characterize the physiology and anatomy of the complex connectivity between thalamic nuclei and their corresponding cortical regions using mouse animal models. The successful candidate for this position would be responsible for dissecting the micro/macro-topology between the thalamus and the cortical microcircuit model using viral manipulations and in slice or whole brain imaging. In addition, the physiology of long-range projections between thalamic nuclei and cortical targets will be investigated using paired recordings and/or channelrhodopsin-assisted circuit mapping (CRACM). After laying the foundation of the thalamo-cortical circuit, the successful candidate will aim to analyze population dynamics of upstream and downstream inputs using calcium imaging and observe functionality of network activity in vivo. Data from this project will be used to create a comprehensive biophysical model of the BBP mouse thalamo-cortical circuit.
     
    Your profile :
    • PhD in Biology, Neuroscience, or related fields
    • Background in Neurobiology research
    • Knowledge of electrophysiology, imaging, and standard laboratory protocols
    • Experience in scientific research of rodent animal models
    • Strong team player and fluent English in speech and writing

    Are nice to have :
    • Background in thalamus research
    • Experience in multiple patch clamp electrophysiology
    • Experience in calcium imaging and/or optogenetics
    • Experience in rodent stereotaxic manipulations
    • Experience in brain clearing and whole brain imaging methods
    • Knowledge of scientific computing software (python, C++)
    We offer :
    • An internationally visible project in simulation-based research in neuroscience having a leading role in the "Blue Brain Project"
    • A young, dynamic, inter-disciplinary, and international working environment
    • Very competitive salary
     
    Start date :
    As soon as possible
     
    Term of employment :
    Fixed-term (CDD)
     
    Work rate :
    100%
  • URL: https://recruiting.epfl.ch/Vacancies/844/Description/2
  • Starts On: Feb. 9, 2019, 8:56 p.m.