Job Information

  • Description:

    A Ph.D. student position is available at the Department of Pharmacology and Toxicology (DPT) of the University of Lausanne to study structure/function aspects of acid-sensing ion channels (ASICs). ASICs are neuronal ion channels involved in pain sensation, the expression of fear, and neurodegeneration after ischemia (for review see Wemmie JA et al., Nat Rev Neurosci 14: 461-471, 2013; Kellenberger S and Schild L, Pharmacol Rev 67: 1-35, 2015). In our laboratory we aim at understanding the molecular mechanisms by which protons activate the ASIC channels. The PhD student will use electrophysiological and optical approaches, in particular the voltage-clamp fluorometry technique (Talwar S and Lynch, JW, Neuropharmacology 98:3-12, 2015) to study conformational changes of ASICs.  The PhD student will also use methods of cell biology and molecular biology. The DPT, with 10 research teams, offers a stimulating and competitive research environment in modern biology with multidisciplinary expertise (www.unil.ch/dpt).

    Start date: July or August 2019 or upon agreement

     

  • Location: Lausanne
  • Starts On: July 1, 2019, 9 a.m.

Job Requirements

  • Skills:

    We are looking for a talented and motivated doctoral student. Experience in electrophysiology (patch-clamp, two-electrode voltage-clamp), optical methods, molecular biology and cell biology is welcome and will be an advantage, but is not a prerequisite.

  • Education Required:

    Applicants should hold a Master or equivalent academic degree that is acceptable for admission as a PhD student in one of the doctoral schools at the Faculty of Biology and Medicine of the University of Lausanne (www.unil.ch/ecoledoctoralefbm).

Company Information

  • Department of Pharmacology and Toxicology, UNIL
    Lausanne Vaud 1011
    Switzerland

Contact Information

  • Stephan Kellenberger
    https://www.unil.ch/dpt/home/menuinst/recherche/groupe-kellenberger.html
  • Contact Method:

    Applications by e-mail are invited in the form of a motivation letter, a curriculum vitae, copies of University exams and degrees, a brief description of laboratory experience and the master thesis, and the names and addresses of two academic references, before April 28. Please note that incomplete applications will not be considered.